VDR is a gene which encodes for a protein which acts as a receptor vitamin D that regulates bone formation and calcium absorption. A variant of the gene known as rs2228570 (FokI polymorphism) is associated with reduced bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and temporal off-and-on occupancy of the VDRE between the two components. It is also modulated by chromosomal position and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes have an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can be a repository of information and documents relevant to legal transactions, business or procedures. Viewing, downloading, or printing are restricted. It uses central computers and an extranet, which is a restricted-access Internet connection, allowing users to access the internet at specified times.
Companies involved in investment banking and in mergers and acquisitions are among the most frequent users of VDRs. VDR. They must be able to share information in a transparent manner with potential investors or buyers. Due diligence may also require a huge amount of information. Life science companies also utilize VDRs for everything from clinical trial data to HIPAA compliance documentation.